Showing posts from 2017

The "omnigenic" model for schizophrenia - why it's even worse than you think.

I'm happy to see the article by Boyle, Yang and Pritchard (Boyle et al, 2017)  getting so much attention. Quite justifiably, many people are commenting on it and I thought I would add my two pence worth. To summarise, I think the main claim they are making is that for a complex disease there will be a relatively small number of "core" genes whose functioning is related to disease mechanisms but that a very large number of polymorphisms will impact to a small extent on these core genes through gene expression networks. This then leads to a phenomenon whereby GWAS hits are very widely scattered through the genome. Most of these hits will not be anywhere near genes involved in disease mechanisms, they'll just reflect impacts on generic expression networks in one way or another. Here, I'd like to add another dimension, taking schizophrenia as an example. My claim will be that as well as the core genes there will be many other genes which do have an effect on risk,

2017 World Congress of Psychiatric Genetics

From: International Society of Psychiatric Genetics [ ] Sent: 09 March 2017 14:34 To: Curtis, David < > Subject: 2017 WCPG Registration Now Open! 2017 WORLD CONGRESS OF PSYCHIATRIC GENETICS OCTOBER 13 - 17, 2017 LOEWS SAPPHIRE FALLS RESORT ORLANDO, FLORIDA International Society of Psychiatric Genetics , 5034-A Thoroughbred Lane ,  Brentwood ,  TN 37027 From: Curtis, David [ ] Sent: Thursday, March 09, 2017 11:54 AM To: Info ISPG < > Subject: RE: 2017 WCPG Registration Now Open! Hi. Sorry, I won’t be coming to the USA while there is a blanket ban on visitors from certain muslim-majority countries and while people from UK seem to be arbitrarily barred on the basis of their colour and/or religion. It’s a shame because I would have liked to attend. Regards - Dave Curtis From: Info ISPG [ ] Sent: 13 March 2017